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The mechanism of human nonhomologous DNA end joining. Murai J, Huang S-N, Das BB, et al. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Heeke AL, Bpd test MJ, Lynce F, et al. Prevalence of homologous recombination-related gene mutations across multiple cancer types.

Abida W, Armenia J, Gopalan A, et al. Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that Minoxidil Tablets (Minoxidil)- FDA affect clinical decision making. Olaparib for metastatic castration-resistant prostate cancer. Mersch J, Jackson MA, Park M, Minoxidil Tablets (Minoxidil)- FDA al.

Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. Castro E, Goh C, Olmos D, et al. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate computer languages. Castro E, Romero-Laorden N, Del Pozo A, et al.

PROREPAIR-B: a prospective cohort study of the impact of germline DNA repair mutations on the outcomes of patients with metastatic castration-resistant prostate cancer. Kim G, Ison G, McKee AE, et al. FDA approval summary: olaparib monotherapy in patients with deleterious germline BRCA-mutated advanced ovarian cancer treated with three or more lines of chemotherapy. FDA approves olaparib tablets for maintenance treatment in ovarian cancer. Accessed July 02, 2021. FDA approves olaparib for germline BRCA-mutated metastatic breast cancer.

FDA approves olaparib for gBRCAm metastatic pancreatic adenocarcinoma. Fong PC, Boss DS, Yap TA, et al. Inhibition of Minoxidil Tablets (Minoxidil)- FDA polymerase in tumors from BRCA mutation carriers. Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Mateo J, Carreira S, Sandhu S, et al. DNA-repair defects and olaparib in metastatic Levothyroxine Sodium (Synthroid)- FDA cancer.

Mateo J, Porta N, Bianchini D, et al. Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair Minoxidil Tablets (Minoxidil)- FDA aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Minoxidil Tablets (Minoxidil)- FDA M, Mateo J, Fizazi K, et al. Survival with olaparib in metastatic castration-resistant prostate cancer.

FDA grants accelerated approval to rucaparib for BRCA-mutated metastatic castration-resistant Minoxidil Tablets (Minoxidil)- FDA cancer.

Abida W, Patnaik A, Campbell D, et al. Rucaparib in men with metastatic castration-resistant prostate cancer harboring a BRCA1 or BRCA2 gene alteration. Abida W, Campbell D, Patnaik A, et al. Non-BRCA DNA damage repair gene alterations and response to the PARP inhibitor rucaparib in metastatic castration-resistant prostate cancer: analysis from the phase II TRITON2 study. Smith MR, Sandhu Minoxidil Tablets (Minoxidil)- FDA, Kelly WK, et al.

LBA50 - pre-specified gov fms analysis of GALAHAD: a phase II study of niraparib in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and biallelic DNA-repair gene defects (DRD). FDA grants breakthrough designation to niraparib for metastatic CRPC. Accessed June 30, 2021.

Bono JSD, Mehra N, Higano CS, et al. Pahuja S, Appleman LJ, Belani CP, et al. Preliminary activity of veliparib (V) in BRCA2-mutated metastatic castration-resistant prostate cancer (mCRPC). Hussain M, Carducci MA, Slovin S, et al. Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer. Hussain M, Daignault S, Twardowski P, et al.

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