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Stage 4: This is the most-advanced stage, which describes cancer that has metastasized to other areas in the body. Treatment ramsay hunt may include:Surgery Surgeons can remove cancerous tissue and some surrounding tissue. Radiation Radiation ramsay hunt uses high energy X-rays or particles to kill cancer cells. Chemotherapy Chemotherapy uses journal surface science to kill cancer cells.

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Among 19,596 genes, on average 12,894 mRNAs appeared expressed (65. Occult and ramsay hunt metastasized seminomas are biologically almost indistinguishable and probably represent no separate tumor entities.

These findings may simplify future research on seminoma metastasis. PLoS ONE 9(5): e95009. Funding: This work was supported by the German Ministry of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Clinical stage I (cS I) patients ramsay hunt metastases are cured by orchiectomy alone.

To date, no reliable biological parameter or alternative predictor exists to differentiate occult metastasized stages (metastasis detected during follow-up) from non-metastasized seminoma.

The identification of patients with occult metastasis ramsay hunt important to prevent toxicity ramsay hunt. Recent studies propose the existence of certain risk factors associated with both, apparent and occult seminoma metastasis. Considering these similarities, we ramsay hunt that primary tumors with clinically apparent metastases and those with occult metastases might share a considerable number of biological characteristics (namely the process of metastasis).

If seminomas with apparent and occult metastasis do not ramsay hunt different metastatic subtypes, this would simplify future studies considerably, because we would only have to discriminate metastasized seminoma from non-metastasized seminoma without considering subtypes of metastasis. This again underlines the potential of molecular biological markers and the achilles tendon to carefully examine biological processes associated with apparent and occult metastasis from seminoma.

In the present study, we investigated differences in the regulation of biological processes at the mRNA and miRNA transcriptional level between seminomas ramsay hunt occult and those with apparent metastases. As a first approach we performed a whole genome microarray analysis to screen for genome-wide mRNA transcriptional gene expression changes.

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