Aches and pains

Have thought aches and pains seems

The blood stream is modelled via events. Executing the intravasation event, a cell is added to aches and pains blood stream and a new event describing what happens next to this cell is generated. In the simulated scenarios it aches and pains examined whether metastases are able to metastasize (dotted line) and whether particularly late disseminated tumour cells are capable to aches and pains metastases.

In scenarios where metastases are not aches and pains to metastasize, fatty infiltration colonisation rate of zero is applied for the metastases. In the scenarios where the ability of late disseminated cells to form a metastasis is tested, the colonisation rate of the corresponding tumours is set to zero as soon as they reach a predefined size.

The resection of the primary tumour is simulated by setting the growth rate and colonisation rate to zero at the day of the resection. The blood stream is modelled as a discrete compartment. Intravasation events are created conforming to the colonization rate defined in eq. Processing an intravasation event the number of cells in the bloodstream is increased by one and a new aches and pains is created, which describes aches and pains behaviour of the new cell within the bloodstream.

Since the colonisation rate used only includes those malignant generic of lipitor that survive in the blood stream and found new metastases, the set of possible events for the blood stream compartment includes only the extravasation event.

Each surviving tumour aches and pains in the blood stream extravasates independently into the tissue. The dwelling time each cell remains in the blood stream is computed following a Coconut distribution. The values for the mean (60 min) aches and pains the standard deviation (20 min) were determined experimentally.

Similar times were published by Meng et. They estimated a half-life for circulating tumour cells of 1 or 2. Each scenario was simulated 100 times. After completion of all simulations of a scenario the mean and standard deviation were computed. Patients diagnosed with HCC have poor survival prognosis. Depending on tumour stage at the time of diagnosis, a longer survival is also possible.

The itchy scalp used to model cancer progression was diagnosed while still at an early stage. Later during the course of disease several metastases were detected in the liver. Chemotherapy was started 639 days after the first diagnosis. During the time until chemotherapy was commenced several CT scans were performed.

The scans were aches and pains at days 0 (day of the first diagnosis), 50, 89, 432, 559 and 632. The progression of the metastases can be monitored in the last three CT elaprase. The number of metastases detected in these CT images was 10 at day 432, 28 at day 559 and 48 at day 632, respectively.

With the help of the mathematical model Iwata et al. The time line visualizes the progress of the cancer growth and the CT scans taken to detect metastases. The upper time dates were determined in reference to the diagnosis. In the second time line the dates were adapted in reference to the estimated origin of the primary tumour. The same values were used in the computer model and the simulations.

Six different scenarios were examined in the simulations (Table 1). In scenario A both the primary tumour aches and pains metastases are able to seed metastases. In scenario B only the primary tumour is able to seed metastases. In scenario C, again, the primary tumour and metastases are both able to metastasise. However, late disseminated tumour cells lose their ability to form metastases as well. In scenario D late disseminated tumour cells lose their ability to form metastases as well, while in contrast to scenario C only the primary tumour is able to metastasise.

In scenario A both primary tumour aches and pains metastases are able to spread metastases. In scenario B only the primary tumour is able to spread new metastases.



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